Atopic dermatitis and the therapeutic methods: A literature review
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چکیده
Atopic dermatitis is an inflammatory skin disease that starts in the early life and usually persists by the end of life in 20% of cases. The disease shows multiple periods of relapse and significantly affects the patient’s quality of life. The etiology of this disease is unknown, yet recent studies have reported incidence of immunological disorders and mutation in the filaggrin gene as the major causes. In some cases, concurrent incidence of infection with these inflammatory lesions reinforces the significance of treatment. Various methods of treatment such as emollients, corticosteroids, and calcineurin inhibitors are applied to manage this disorder. Traditional and complementary approaches also may help controlling the disease. This disease is not usually easily controllable, thus requiring full awareness of physicians of the underlying prospects of this disease. This review paper deals with the important aspects of the clinical perspectives and presents an integrative therapeutic approach for treating atopic dermatitis.
منابع مشابه
A short review on immunology of Atopic dermatitis
Atopic dermatitis (AD) is a pruritic, relapsing, chronic disease that arises most commonly during infancy, childhood, or adolescence. It is clear that genetic factors are important in AD, a family history of AD, allergic rhinitis, and/or asthma and other “Atopic” phenomena being common in patient with AD. The two main pathogenetic characteristic of AD are: I) IgE-mediated antigen dependent “Spe...
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Background: Atopic dermatitis is a chronic, recurrent inflammation of the skin, accompanied by severe pruritus. Immune system dysregulation and skin barrier defects are associated with the abnormalities in atopic dermatitis. Myriad pieces of evidence have pointed to the major roles of LL-37 and interleukin-31 (IL31)in atopic dermatitis. The studies on atopic dermatitis are still limited i...
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Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such a...
متن کاملSpecific IgE to Common Food Allergens in Children with Atopic Dermatitis
Background: Atopic dermatitis is a major public health problem, often starting in early childhood and sometimes followed by other allergic diseases. Although hypersensitivity to foods is assumed to play an essential role in the development of atopic dermatitis in some patients, little is known about common food allergens in Iranian children with atopic dermatitis. Objectives: This study was des...
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تاریخ انتشار 2016